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I have designed a DC to DC converter on proteus. If I set 4V input voltage, output is 22V at 10kHz, but this output voltage is not constant. How to get a constant voltage output from a DC to DC converter?

EDIT to show the linked circuit:

enter image description here

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Then you haven't designed what you want - I suggest you link to a picture of your schematic or maybe try adding an LC low pass filter at the output to convert to a smoother dc. – Andy aka Aug 15 '14 at 9:14
sorry i cannot share the picture for the schematic, because there is no option given here. – dani Aug 15 '14 at 9:25
Post the picture on your favourite share site and add the link to your question - someone with enough reputation will embed it into your question. – Andy aka Aug 15 '14 at 9:27
here is the link for the schematic tinypic.com/r/35lb19t/8 – dani Aug 15 '14 at 9:35
To achieve regulated DC output, you need a control loop that samples the output voltage and drives the switch with an appropriate waveform. This controller could vary the switching frequency, vary the pulse width, or even skip pulses. That's what a Switch-Mode Power Supply (SMPS) controller IC does. – MarkU Aug 15 '14 at 9:47

Your circuit is the bare minimum to produce a boost output voltage - there will always be ripple in this type of circuit and if you want lower ripple try making the output capacitor bigger. If you really want a more stable output than what can be gotten from a bigger output capacitor then your switching frequency of 10kHz would need to rise considerably - typically, modern chips do this and switch at many hundreds of kHz and even a couple of MHz.

Ultimately, if you need a clean and quiet supply to can add a linear voltage regulator after the booster.

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