It often helps to re-draw the circuit in a way that makes more sense to you - it may take several tries to see the "real" circuit arrangement.
When I re-draw your circuit, the first thing I do is arrange it so that electricity flows from left to right, as God intended. :)
simulate this circuit – Schematic created using CircuitLab
Here we can see that R5 is simply between Vin and Ground, so has no effect on the rest of the circuit. R4 and R3 form a voltage divider, which feeds another voltage divider consisting of R2 and R1. If you had some values for the resistors and for Vin, it would be simple to calculate Vout.