I'm making a small board for a DC / DC converter. Can I tie -Vin and -Vout together and think of them as GND? Is there some noise advantage to keeping them separate?
Edit: the converter one of the Murata UWE series linked here, the UWE-12/6.
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Yes, this is fine to do if you don't need isolation between the input and output sides of the converter. For the situation you describe (small battery-powered device) there's likely no EMI advantage to keeping them separated.