EDITED TO CORRECT U1A ERROR
Let's assume that U1A and U1B are operating "normally" - that is, their resistor networks have appropriate voltages. U1A has the + input grounded, so the - input must be grounded as well.
Now look at U2. The upper end of R1 is held at ground (well, virtual ground), so U1B acts as a standard non-inverting op amp, with gain of 51. With an input of 2 volts, the output of U1B must therefor be at 102 volts. I'm sure you'll agree that this will be difficult to do with a 12 volt power supply.
Since the voltage across R1 is 2 volts, 1 mA must flow through it. 1 mA through R2's 100k will drive the output of U1A to -100 volts. Again, I'm sure you'll agree that this will be difficult given the power supply.
So the difference amplifier U1C will take the difference of 102 and -100, for a nominal output voltage of 202 volts. Again, I'm sure you'll etc, etc, etc. While this is exactly what is predicted for circuit (a gain of 101 times 2 volts is 202 volts), none of the op amps is able to perform as their resistors require due to the limitations caused by your choice of power supply and op amp. If you had a power supply of +/- 250 volts and op amps to match, you'd be fine. Instead, each op amp is limited to much lower voltages, and changing R1 just doesn't help. Although if you increase R1 to about 100k you'll get something sort of right, or at least you'll be able to see changes in the output with varying R1. Since U1A cannot produce negative voltages the circuit still won't work properly, but at least things will change enough to see them change. If you connect pin 11 to a -12 volt supply you'll be able to play with R1 at 100k.
So try your simulation with U1A's + input tied to 2 volts, and U1B's input at 2.05 volts. This will, if the theory is correct, give you an output of about 5 volts, or halfway between V+ and ground, which is a handy place to start. Now you can play with R1.
But be careful. Remember those offsets I mentioned? For a 324 this can be as much as 3 mV. This won't matter a whole lot for U1A, but it represents more than 50% of the difference between the two inputs, so your nominal 5 volt output could be +/- 3 volts. You'll have to take this into account, unless your simulator allows you to set the offset to zero.