The insulated and uninsulated ferrules are identical in all other ways except for the missing insulation and size colour key.
Using the terminal screw, pliers or a special tool all work if you are only going to terminate them once.
If you plan to re-terminate them a number of times then he special crimping tools are well worth using as they make the termination firmer and it does not deform as much when screwed down, then when later removed it will be in better condition to reinsert.
There are many 1, 4 and 6 jaw crimping tools that are specifically designed for the job and for light duty or occasional use the cheaper ones may be enough. In standards compliant production a good quality name brand crimper will be a sound investment and last for years.
There are also the bare brass U shaped roll crimp terminations that are usually machine crimped and fed from a bandolier. They are often found in large volume consumer devices and I find them to be more reliable as they are near impossible to pull out compared to the thinner wall tinned brass bootlace type ferrules. They are rarely used in small volume or prototype work though.