I use Altium Designer 18. When I open a project file (.PrjPCB), the asterisk ("*") appears next to the project name indicating that the project has been modified, but I haven't actually made any changes.
I've been using Altium for years, and I've always wondered about this. I'd really like to change this if possible, because I sometimes worry that I've somehow accidentally made changes to the project that I didn't intend.
EDIT: I'm aware that in some cases, Altium can't find the library files that are linked to the project and removes those from the project. This is not what's happening in this case. Often, when I open a project, and no library files are removed from the project, the project is still modified and (even if I don't make any changes), I'm asked if I want to save changes to the project when I close Altium.
Also am not making changes to any of the project files (.SchDoc files, .PcbDoc files, etc).
xxxx.xxx could not be found and will be removed from the project.
Are you getting any of these messages? If so, when the file is removed it modifies the project so it recognizes it as a change. \$\endgroup\$