My concern is that pins are connected between DB25 and TXS0108E, but are not connected between TXS0108E and the Header 5x2. There is only the tracks between TXS0108 and the Header 5x2, but there is no connection, the pins were not all soldered.
I can not guarantee that the respective pins connected to DB25 will not be energized, eventualy they can be. So, my doubt is, is there a problem if some pins connected in the DB25 does not have their respective pins connected to Header 5x2 ? This way they will be floating in on side and not in the other of the TXS0108.
Below is the circuit to illustrate.