I see a lot of discussion about using copper pours on the outer layers of a multi-layer PCB, as well as a single continuous ground plane on a multi-layer board, but there isn't a lot of information out there about ground pours on the internal signal layers.
For example, take a standard 6-layer PCB stackup:
Signal
Prepreg
Ground Plane
Core
Signal
Prepreg
Signal
Core
Power Plane
Signal
Where the top internal signal layer looks like this:
This signal layer contains the high-speed signals (SQI, USB, and Ethernet), as well as some other low-speed digital traces (GPIO). Should this layer also have a ground pour? Would this help isolate the digital traces, or would it cause more interference/coupling?