Impedance matching starts to matters when the following three criteria are satisifed, all relative to each other:
- the propagation time is slow enough
- the wavelength is short enough
- the connection length is long enough
In other words, when you can no longer assume the wave propagates down the line instantaneously and that the potential at both ends of the line are always equal. Imagine a single frequency component of a signal, a sinusoid, being sent down a line. It's not a constant voltage. Its amplitude varies as you go.
In more qualitative terms, it means that when these criteria are satisfied, the driver is placing "new bits of waveform" onto the line faster than it takes for conditions on far end of the line to propagate back to the driver. This means you get reflections bouncing back and forth as the two far ends "negotiate" with each other to form an equilibrium and the driver adjusts its output to accommodate the conditions at the far end of the line.
Actually, I lied. This doesn't only happen when the criteria is satisfied. It always happens since it always takes some amount of time for the conditions at the far end to propagate back to the driver.
The reason it doesn't matter so much when the criteria are not satisfied is that the reflections are able to settle down fast enough that it doesn't corrupt your signal or cause ringing that is high enough to be damaging. But as the line gets longer relative to the wavelength, the mismatch between the ends gets larger the magnitude of the reflections become more problematic. Imagine a sinusoid of any frequency and put it down a wire and freeze it in time. If the wire is 1/4 the wavelength, one end could be at Vpk and the opposite end could be as high as -Vpk for a total difference of 2Vpk. But if the wire is 1/100th the wavelength the difference is a lot smaller.
Same thing happens when you suddenly slam off the faucet in your house. You might hear the pipes rumble from the water hammer of the closed valve stopping the inertia of all the water flowing in the pipes rippling down the pipes because the far end of the pipe (and indeed all the water in the pipes) didn't know to stop flowing the instant you slammed the faucet shut.
A mechanical analog of this is if you pump water into a long pipe that narrows in diameter (or simply becomes a dead-end) far away from the inlet. At the inlet, the water appears to flows smoothly before the water reaches the blockage (as if the pipe was infinite, like an infinitely long transmission line). But when it reaches the blockage, the all the force behind the inertia of the water water splashes against the blockage and sends a ripple all the way back to the inlet, effectively giving you information about what is at the far end of the pipe and telling you that that you need to decrease your input flow rate.
So the reason it matters for RF is because RF is very high frequency and that usually means that pretty much practical all connection lengths long enough relative to the wavelength for impedance matching to matter.
But from the criteria, you can see that it is not just RF that is subject to this criteria. So 2MHz sine wave over a 30cm line is okay without impedance matching, but over 1000km, not so much.
Note that the 2MHz RS-422 you are talking about is a 2MHz square wave (more or less) but 2MHz is the fundamental; the lowest frequency present. However, from the first paragraph, it should be obvious that the highest frequency you care about is the one that will cause troubles first. The highest frequency sinusoidal component in your 2MHz RS-422 is found hidden within the rise time of the square wave, and therefore the rise-time (and by extension the highest frequency component) is the determinant in whether impedance matching is needed.