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The PCB has a pulse oximeter mounted on the surface, and it's tolerance is 0.6mm. The problem is the pulse oximeter needs to touch the bottom case at all times. How to best mount the PCB in the case without putting too much stress on the pulse oximeter? Will screws with flexible washers be all right? Sadly separating pulse oximeter from main PCB is not an option.

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    \$\begingroup\$ This question is almost entirely mechanical. One idea is closed cell foam. Another is spring clips. Spring clips would be more reliable over a long time period. Foam might break down over time. But you probably need to talk to a mechanical engineer and show them all the details. \$\endgroup\$
    – user57037
    Feb 26, 2021 at 7:19

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I would put a machined guard around the pulse oximeter to keep the surface from it at about 0.2-0.3 (if it is and SMD part soldering height tolerance is about 0.2mm) and then simply screw down the resulting assembly.

Otherwise use weak springs to push the p.o. against the case, need to know the allowed stress on the body for that

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