I am struggling with instrumentation amplifiers. Particularly, I would like to know

  1. what defines an instrumentation amplifier
  2. what kind of circuit configuration could be classified as an instrumentation amplifier
  3. how does an AD524 work.

In fact, firstly I've seen the so-called INA111, the circuit of which, available in its datasheet, is reported in the following picture

enter image description here

Where \$R_{\text{gain}}\$ is an external resistance to be connected to two proper leads of the integrated circuit and it's used to adjust the gain.

Later on I've noticed that even Wikipedia provides a page named "instrumentation amplifier" which also shows the some gain and the some circuital configuration of the INA111.

So I thought "this circuit is an instrumentation amplifier". But later I realized that something is wrong with this...

By the way, I also figured out how to calculate its gain, by calculating separately each one of its parts, as reported here

  1. "blue part" gain

$$ \qquad V_{o1} = \left( 1 + \frac{2R_1}{R_{\text{gain}}} \right)V_1 - V_{m}\frac{2R_1}{G_{gain}}\\ $$

  1. "green part" gain

$$ \qquad V_{o2} = \left( 1 + \frac{2R_1}{R_{\text{gain}}} \right)V_2 - V_{m}\frac{2R_1}{G_{\text{gain}}} $$

  1. "red part" gain

$$ \qquad V_+ = \frac{R_3}{R_2}V_{o2} $$

  1. "orange part" gain

$$ \qquad V_{\text{out}} = \left( 1 + \frac{R_3}{R_2} \right)V_+ - V_{o1}\frac{R_3}{G_2} $$

subtracting the "blue part" with the "green part" and using the other two equations to eliminate \$V_{o1}\$ and \$V_{o2}\$ the total gain I get is

$$ G = \left(1 + \frac{2R_1}{R_{\text{gain}}}\right)\frac{R_3}{R_2} $$

which is in agreement both with Wikipedia and the INA111 datasheet.

But afterwards I faced the AD524, which still is classified as an instrumentation amplifier, but its internal structure is

enter image description here

Not only is it not the previous circuit configuration anymore, but also I do not recognize inverting, non inverting or differential configurations. I don't know how to calculate its gain neither I do not know how does it work. Furthermore, I do not properly understand how to connect many of its leads.

So now, how do I understand its behavior? How do I calculate its gain?

  • 1
    \$\begingroup\$ The first paragraph of the wikipedia entry seems to provide a decent definition of what an Instrument Amplifier is. Do you have some specific point you would like clarified? \$\endgroup\$
    – user57037
    Commented Feb 26, 2021 at 19:30
  • 2
    \$\begingroup\$ from what I understand, the primary characteristics of an INA are: differential amplifier designed for quantitative use with input signals that are low voltage and high impedance, usually at modest frequencies. The must-have attributes: accurately controlled and stable gain, design allows possibility of high gain (often 100x or more), low offset, good CMRR, high input impedance, and noise characteristics. This can be accomplished with different circuits, i.e. 2,3,4 op amps \$\endgroup\$
    – Pete W
    Commented Feb 26, 2021 at 19:40
  • \$\begingroup\$ According with Wikipedia, an instrumentation amplifier has two buffer amplifiers as input. Now, how does that couple of opamps for each input provide a buffer amplifier Is not clear to me. Furthermore a solution for the impedance matching Is already provided by a simple non inverting opamps. So why should I prefer a so complicated instrumentation amplifier ti the much more Easy non invertono amplifier? \$\endgroup\$ Commented Feb 26, 2021 at 20:01
  • 4
    \$\begingroup\$ the basic non inverting op amp configuration is not differential. The basic differential configuration (with high gain) is not hi input impedance. \$\endgroup\$
    – Pete W
    Commented Feb 26, 2021 at 20:22

3 Answers 3


An instrumentation amplifier is a difference amplifier (your orange box) with buffered inputs (your blue and green boxes) to achieve higher input impedance than a simple op amp difference amplifier1. There are two basic architectures: the three op amp one you show, and a two op amp version (see, e.g. here). You can build one out of discrete op amps or use a in amp IC (the latter is usually better). In amp ICs often have a variety of features to make them easier to use, more accurate, etc., and the AD524 has a number of those features.

The AD524 is based on the three op amp architecture, but its inputs use two op amps each to achieve a double inversion. Its datasheet explains why the "preamplifier" is designed this way under the "Theory of Operation" section on page 15.

The datasheet also explains how the gain is determined in the "Gain" section starting on page 16. You can either connect an external resistor to to pins RG1 and RG2 to set \$R_{\text{gain}}\$ (the datasheet provides the formula), or you can short RG2 to pin 11, 12, or 13 to set the gain to 1000, 100, or 10, respectively (or leave RG2 open for a gain of 1). The latter method offers only limited gain choices but eliminates the need for an external resistor and is more accurate because it uses only the internal, trimmed resistors.

Another unusual aspect of the AD524 is the SENSE pin, which is normally shorted to the OUTPUT pin (most in amps do this internally) but can be connected directly to the load for better accuracy. This is explained in the "Sense Terminal" section on page 18.

In short, it's best to read the datasheet to understand how the in amp works.

1 This is a simple op amp difference amplifier, which does not have buffered inputs:

op amp difference amplifier

The input impedances of this circuit are determined by the resistors and is therefore lower than the input impedance directly at the input of an op amp input (the latter is what you get with an in amp).


Your dissection is a bit 'off', all four resistors (orange box + red box) and the op-amp form the differential amplifier. When SENSE is connected to the output and REFERENCE is grounded, that portion of the AD524 is identical to the output section of the typical 3-amplifier in-amp, and the output is Vin(+)-Vin(-) where Vin(+) and Vin(-) are the internal nodes connected to the output differential amplifier.

The compound amplifiers and the Vb voltage shown in the front end are there to inform people who understand that internal nodes generally cannot exceed the supply rails that this amplifier is a bit different and will not saturate under certain conditions. In normal operation you can ignore the Vb and second amplifiers and think of each as a single amplifier if you note that the signal is inverted.

The differential gain of the 2 compound amplifiers is similar to the front end of the 3-amplifier instrumentation amplifier. Differential gain is (40K+Rg)/Rg = 40K/Rg + 1. Since the output section is a gain of 1 differential amplifier, that is also the gain to the output.

The tolerance of the 40K is loose, +/-20%, so AD provides some matched internal resistors which you can use. They are matched in the sense that the ratio to the 20K resistors is relatively accurate (see the datasheet for exact gain accuracies). So if we have 404 ohms, the gain will be 40404/404 ~= 100.0. You strap the desired resistor in for gains of 1, 10, 100, 1000 (for a gain of 1 Rg is left open).


The AD524 cascades two inverting differential amplifiers but with negative feedback thru RG2 with optional jumpers.

Thus this inverts the -ve inputs to +ve inputs. The 2nd pair are biased on Vin+ to match the Vcm output of the 1st pair .

Gain is thus defined as (20k+20k)/Rg +1 so open is unity gain and Rg=40 is a gain of 1001. But is probably laser trimmed to ~39.99 Ohms.


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