I have a specific application where I need to interface 256 i2c busses arranged in array of 16x16. I have used multiplexers to create LED arrays, but this problem seems different as there isn't part of the circuit to pull to ground as one would for LED's. If I had to only "write" to bus then it could be achieved with array of diodes, but I need to also read from the bus. I started to sketch something using transistors, but my hobby level knowledge was not enough to figure this one out. Best solution I could come up is adding currents from both muxers to trigger the transistor.
This is my best idea so far. Using a voltage divider thru both muxes to break thru mosfets threashold: