There are two challenges:

1. Latency

  USB has two orders of magnitude higher latency than PCI. Many PCI drivers assume memory mapped access to registers on the PCI card with the CPU blocking on the bus transaction. Unmodified PCI drivers over a PCI-over-USB bridge are likely to fail because of wrong latency assumptions.
  
  Check this [study on PCI latency][1]: PCI mean latency is in the order of 400ns, PCIe mean latency is in the order of 2000ns. [USB 3.0 latency according to the article you linked][2] is in the order of 30us.

2. Bus vs. Packet Network

  While PCI is a bus, PCIe and USB are packet based networks. The PCIe root bridge hides the complexity of a packet network and presents the CPU with something that looks like a bus. Doing the same thing over USB is certainly possible, but if you want binary compatible drivers your hardware interface towards the CPU has to look more or less like PCI and you will end up with something like a PCIe root bridge. This is probably not something that can be achieved by common USB chipsets with *HCI interfaces.





  [1]: http://cl.cam.ac.uk/~awm22/publications/miller2009motivating.pdf
  [2]: http://stackoverflow.com/questions/13831008/what-is-the-minimum-latency-of-usb-3-0