Although in the paragraph you emphasized, they use the word `and`: > The MSSP module can operate in **one of two** modes: > - Serial Peripheral Interface (SPI) > - Inter-Integrated Circuit (I2C™) [Datasheet][1], page 164. But probably you can software implement the I2C protocol on other pins. [1]: http://ww1.microchip.com/downloads/en/DeviceDoc/41607A.pdf