Is it possible to use a PCB pad as a button? I think of using it to switch on a curcuit that is only supposed to be enabled, when the user holds it in its hands.

As inspiration, I used the pads that are being used on soft touch buttons on keyboards or in calculators:

[![enter image description here][1]][1]


  [1]: https://i.sstatic.net/L2AQJ.jpg

I know that the human body has a quite high resistance, so what would be an appropriate circuit to detect the touch input? Bare hardware only. I don't withant to use any microcontroller here.