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Nov 21, 2019 at 0:36 comment added MarkU With such poor linearity, there is no value in trying to cascade these ADCs. The INL and DNL are just barely adequate for a cheap 12-bit SAR ADC. You’re better off buying an external delta-sigma ADC to get high 24-bit resolution with appropriate dynamic range for the signal you want to measure. Many delta-sigma ADC are available with internal PGA (amplifier), which is more likely what you actually need.
Nov 20, 2019 at 22:54 comment added neerajb The MCU is ATXMEGA256A3U. It has a 12-bit ADC which can be configured for 8-bit and 10-bit with single-ended and differential mode. I was wondering if we lower the reference voltage, it will improve the resolution but the reference voltage cannot go below 1V. Which is why I probably have to get an external ADC. I can amplify the signal which is basically taken from a chemical reaction and should be around 0.5V but to improve the resolution from 8 to 16 bit or even 12 to 24, I don't think ADC will be able to take in that large of a value. Let me know if I'm not clear about something.
Nov 20, 2019 at 21:57 comment added Marcus Müller @neerajb Really, describe what you're trying to do: You don't get better measurement resolution by making your measurement device worse, but by increasing the signal amplitude, you really have some misconceptions. I bet some of the challenges you face are easy to solve, but you just leave us in the dark. Don't do that!
Nov 20, 2019 at 21:44 vote accept neerajb
Nov 20, 2019 at 21:43 comment added neerajb The minimum reference voltage should be 1V. That means I won't be able to improve the resolution by lowering the reference. I guess that answers my question.
Nov 20, 2019 at 21:17 history edited The Photon CC BY-SA 4.0
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Nov 20, 2019 at 21:14 comment added The Photon @MarcusMüller, and never mind that the noise floor is probably above 50 uV, and ...
Nov 20, 2019 at 21:12 comment added Marcus Müller And half of the input range won't sensibly be quantized, if OP's input voltage range is actually symmetric around 0V...
Nov 20, 2019 at 21:12 history answered The Photon CC BY-SA 4.0