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I²C (Inter-Integrated Circuit) is a multi-drop serial bus invented by Philips (now NXP) for communication between ICs on the same PCB, i.e. short distance.
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TCA9548A : power down while pull-up resistors are still supplied on one side
On one side of the TCA9548A there is the SoC (XIAO SAMD21), with its I2C pulled up to 3.3 V, and on the other side there are many MCP4728s with their I2C pulled up to 5 V. … When I power down the SoC, I'd like to power down the TCA9548A too (to avoid a second 3.3 V LDO just for the TCA), while the MCP4728 are still powered and with the I2C pulled-up to 5 V. …
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TCA9548A : power down while pull-up resistors are still supplied on one side
Here is a Texas Instruments engineer's answer :
"Having a pull-up voltage above VCC is OK, with any VCC, even 0 V."