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TCA9548A : power down while pull-up resistors are still supplied on one side
To keep RF as low as possible in a music synthesizer, I power down the SoC (XIAO SAMD21) which performs autotune once the autotuning procedure is completed. … On one side of the TCA9548A there is the SoC (XIAO SAMD21), with its I2C pulled up to 3.3 V, and on the other side there are many MCP4728s with their I2C pulled up to 5 V. …
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TCA9548A : power down while pull-up resistors are still supplied on one side
Here is a Texas Instruments engineer's answer :
"Having a pull-up voltage above VCC is OK, with any VCC, even 0 V."