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In serial communication data is transmitted as a sequence in time. Main advantage: much less wires needed. Main disadvantage: Higher bandwidth for the same throughput.
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STM32F7 Discovery USB CDC using CubeMX
That's because from stm32f4-discovery link you gave, precompiled hex file has enabled USB clock and also PLL configuration is properly set to ensure 48MHz is enabled for USB, if you are using USB FS M …