It depends on if vibration exists and causes the wire to move how rugged the attachment must be. Normally a 5 to 10 lb. pull test is the criterion for any connection, whether it is twist wire clamped or crimp lug attached with proper two-stage crimp on insulation and conductor.
Even molded connector junctions can and often do fail due to designers under-estimating how much strain users actually apply to their DC power cords on laptops or iPads (I have had to replace mine often from grandkids and my frequent use).
If this describes your situation, then do not tin but neatly twist,
shape (with tool or needle-nose or plastic barrier wall) and clamp
under screw head for an air-tight pressure contact with sufficient but
not excessive force to pass pull test. This will translate into a
fixed screw torque level with calibrated production tools or
training.Better terminal strips have barriers and crimp washer under
screw head.
However in my own practice, I prefer a thin solder dip or coating so that it wicks under the insulation and a star washer. The solder wicking adds strain relief. The star washer exerts more contact pressure and the solder mitigates loose strands.
Careless loose strands can only be avoided by proxy inspection or a better design with crimped terminals and routine pull tests.
If rugged strain relief is needed to prevent frayed wire breakage, then additional cable plastic clamp strain relief is needed such that the stiffness on strain relief is about <5x stress/strain of the wire for a graduated relief. This can be a moulded jacket as well.