To keep RF as low as possible in a music synthesizer, I power down the SoC (XIAO SAMD21) which performs autotune once the autotuning procedure is completed.
On one side of the TCA9548A there is the SoC (XIAO SAMD21), with its I2C pulled up to 3.3 V, and on the other side there are many MCP4728s with their I2C pulled up to 5 V.
When I power down the SoC, I'd like to power down the TCA9548A too (to avoid a second 3.3 V LDO just for the TCA), while the MCP4728 are still powered and with the I2C pulled-up to 5 V.
Is it OK for the TCA to have pull-up resistors still supplied when its power is off?