As Mark said, if you want to look at the distortion of a 20kHz sine wave with 1Vpp you get about 0.125V/us every Vpp. It depends how much your output peak-peak is. Because your amplification is only 5 times, I don't think you're going for 30Vpp but more something like 10Vpp?
Because you're amplifying audio, you could use an AC coupling so you don't have to worry about the offset very much. The noise can be significant, but not with these amplifications. You can calculate the RMS noise RTI according to your bandwidth:
e_noise = sqrt(Bandwidth) * NoiseFigure (nV/sqrt(Hz))
So your Bandwidth = 20kHz (ideal situation, a simple low pass will add penalties), your noise figure is for example 50nV/rt Hz (not counting 1/f noise), which means your RTI (input) noise RMS value is 7.071uV. If you amplify the signal by 5 times, you RTO (Output) noise, taking away external noise sources (resistors, etc.) you get 35.4uV rms noise added. At this gain and bandwidth, that isn't very much, but please note that your input noise (from the source) may already be 120uV, which means you would get 0.6mV RMS noise at the output.
Noise becomes a significant factor at high gain and/or higher bandwidths.