I would start with the output requirements, the available power supply, the efficiency requirements, then go back towards the signal sources, as follows:
Step 1.
What type of load are you driving, and to what power level?
For example: let's assume the output device (the one that makes the sound you hear) is a single 8Ω electro-dynamic speaker rated at 20W continuous. Do you want to drive it to its full power rating? If so, then you will need to drive its terminals to +/-18V peak (sinewave of 12.7Vrms).
However, if the load is a speaker enclosure rated overall 20W and it contains three electro-dynamic drivers (speakers) and a cross-over network, then the amplifier may need more power than the case of driving just one speaker coil. This is due to the cross-over network; it is not perfect at splitting the power evenly as required to all three speakers across the entire frequency range, plus it introduces its own distortions and EMC issues. For that reason, I would favour removing the passive cross-over, having a separate amplifier connected to each speaker (so three per speaker cabinet, six for a stereo system), and feeding each amplifier its own input from a small-signal frequency cross-over done using good-quality analog circuits and ICs.
Another example: your load may be a headset, rated 32Ω 0.2W. The power requirements for this are an order of magnitude lower than the previous example. Usually, I design for the worst-case (heaviest) load required, then introduce resistors at the output ports as required to reduce the maximum power delivery to the lighter loads just to ensure the beefy amplifier doesn't destroy the little load.
Step 2.
Next, consider your power supply, and efficiency requirements. Why are they related? Well, suppose both of the following conditions are true:
(a) plenty of power available (at the correct voltage),
and
(b) plenty of room to mount good heatsinks on the amplifier.
In that case, both power efficiency and power dissipation are of no concern, so that allows you the freedom to select any one of the various classes of push-pull linear amplifiers to drive the load, eg: class A, B, or AB; of course, for low distortion and good sonic performance choose either class A, or class AB, for the latter the sonic performance may be improved by increasing the idle current at the expense of more standing power loss and increased heat load.
However, if either of these conditions are not true, then you may have to consider a more efficient amplifier class, such as Class D, G, or H. Class D involves very high-speed switching, and therefore is an order of magnitude more difficult to design than Class A, B, or AB; having said that, there do exist many chip-sets that do a good job of integrating much of the difficult stuff - but hey, where's the fun in that?
What is the output voltage of your power supply? For example, is it a 12V battery charger? In that case, the maximum output power an amplifier can deliver into an 8Ω load from this supply is very limited, particularly if the output is single-ended (one end of the load tied to 0V GND), simply because the voltage is so low - regardless of how much current the power supply can deliver. Your options to boost output power in this situation are:
A. Apply two amplifiers configured in a bridge, ie: drive both ends of the load; this can double the output voltage which increases the output power by a factor of 4 for a given load.
B. Include a power converter to boost the voltage rails to the amplifier.
Step 3.
Now consider the input signal to your power amp. To be compatible with outputs from most modern-day (last 50 years!) audio equipment, choose either of the two main standards for line-level input: domestic (-10dBV, or 0.316Vrms, 0.89Vp-p), or professional (+4dBu, or 1.23Vrms, 3.47Vp-p). Or you can design for both, and have a selector switch or separate input jack.
Step 4.
At the end of this process, your answer for what the output of each signal source should be is quite simple: it should match the input of the power amplifier, which is just the standard line-level you selected at step 3. You may need to attenuate or boost the output of the existing signal sources you now have to achieve that.
Further reading:
This link gives some advice on designing a simple amplifier from common parts to deliver 1W into 8Ω at reasonable sonic quality from a 9V battery:
https://electronics.stackexchange.com/a/688822/341959