As far as I can see, all the thick red MOSFETs have their drains connected to the red POWER network and their gates connected to their sources. This makes sense if the symbol means they are depletion MOSFETs - they are used as "depletion loads" which are current limiters. If you build this circuit out of discrete components it will be more convenient to use resistors in their place. I've been told that building logic gates with resistor loads makes them slower, but I'm guessing you don't care about that very much. You could use JFET constant current circuits or something like that, if you really wanted to.
If you find one that isn't wired like this, then it's doing something different and you can't necessarily replace it with a resistor.
If you know how to make logic gates out of MOSFETs then you already know why each logic gate has something like a resistor in it - it brings the output high by default, when the transistors aren't forcing it to be low.
P.S. The big array of transistors on the left side can be replaced by an array of diodes, resistors, and fewer transistors, if you like.
P.P.S. although you can make a 6502, I think you might be underestimating the sheer amount of wiring needed. Looking at a schematic is all well and good but you have to actually solder all these wires and that could take days or weeks. And if you make a mistake you have to find the mistake.
P.P.P.S. You also need to somehow assemble the thing. If you just have a loose tangle of transistors and wiring, they will touch each other and cause short circuits. If you are willing to order some more parts, you could consider perfboard, stripboard or any similar product (many manufacturers make it in different patterns). You'll need many pieces as your project will be big. If you want to only use home materials, you could poke the legs through (corrugated?) cardboard as a makeshift circuit board. Ground the cardboard while working on the circuit. Professionals will laugh at grounding cardboard to prevent ESD, but it's not the worst material...
(Edit: Actually it may be too difficult to poke MOSFET legs through corrugated cardboard. Maybe use normal thickness paper, and reinforce it afterwards by gluing cardboard onto it. IDK - when you go to build it, you'll find what works and what doesn't. I assume you don't want to get a proper circuit board made because it's expensive)